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Guillain-Barre Syndrome (GBS) – Autoimmune polyneuropathy that results in widespread demylination of peripheral nerves

Typically occur 1 week after a triggering infection

Paresthesias/Neuropathic Pain -> Ascending symmetric paralysis -> Respiratory Failure

Major Diagnostic Criteria

  1. Progressive limb weakness in multiple limbs that is relatively symmetric
  2. Diminished/Absent deep tendon reflexes in affected limbs
  3. No alternative diagnosis
  4. CSF studies have false-negatives – May see albuminocytologic dissociation (Elevated protein with normal cell counts)

Treatment – IVIG and monitor respiratory status